Neem bark is safe anti- infective and anti- inflammatory. It regulates pro-inflammatory enzymatic activities, including cyclooxygenase (COX) & lipoxygenase (LOX) enzymes and is useful in management of skin diseases, sores and wounds.
Its phytoconstituents has a significant role in the management of cancer through the regulation of cell signalling pathways. It modulates the activity of various tumour suppressor genes, angiogenesis, transcription factors and apoptosis.
It neutralises free radicals & stabilise the reactive oxygen species before they attack any biological system. It helps to activate antioxidative enzyme & has an inhibitory effect on bacterial growth & the breakdown of the microbial cell wall.
By regular use of Neem, significant protection is evidenced by the decrease of elevated serum alanine aminotransferase, aspartate aminotransferase, gamma- glutamyl transpeptidase, alkaline phosphatase, total bilirubin, creatinine, uric acid & urea.